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Related Experiment Video

Updated: Jun 7, 2026

Measurements of Physiological Stress Responses in C. Elegans

Measurements of Physiological Stress Responses in C. Elegans

Published on: May 21, 2020

Autophagy and the integrated stress response.

Guido Kroemer¹, Guillermo Mariño, Beth Levine

¹INSERM, U848, 39 rue Calmette Desmoulins, 94805 Villejuif, France. kroemer@orange.fr

|October 23, 2010

Summary

Autophagy is a cellular process for degrading damaged components, activated by various stresses. It integrates with other cellular stress responses, acting as a key part of the cell

Area of Science:

Cell Biology
Molecular Biology
Biochemistry

Background:

Autophagy is a fundamental cellular process involving lysosomal degradation.
It clears damaged organelles and cytosolic components.
Autophagy is crucial for maintaining cellular homeostasis.

Purpose of the Study:

To elucidate the regulatory mechanisms of autophagy.
To understand how autophagy integrates with other cellular stress responses.
To highlight autophagy's role in the integrated stress response.

Main Methods:

Review of signaling pathways governing autophagy.
Analysis of stimulus-dependent and independent regulation.
Examination of cross-talk between autophagy and other stress responses.

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Published on: June 14, 2024

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Last Updated: Jun 7, 2026

Measurements of Physiological Stress Responses in C. Elegans

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Published on: May 21, 2020

Measuring Endoplasmic Reticulum Stress and Unfolded Protein Response in HIV-1 Infected T-Cells and Analyzing its Role in HIV-1 Replication

Measuring Endoplasmic Reticulum Stress and Unfolded Protein Response in HIV-1 Infected T-Cells and Analyzing its Role in HIV-1 Replication

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Main Results:

Autophagy is triggered by diverse cellular stresses like nutrient deprivation and hypoxia.
Specific and general signaling pathways coordinate autophagy.
Autophagy integrates with other stress responses via parallel or mutual control.

Conclusions:

Autophagy is a central component of the integrated cellular stress response.
Its regulation is complex and involves multiple signaling networks.
Understanding autophagy is key to comprehending cellular adaptation to stress.