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Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging
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Diffusion tensor imaging and tract-based spatial statistics in obsessive-compulsive disorder.

Takashi Nakamae1, Jin Narumoto, Yuki Sakai

  • 1Department of Psychiatry, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kajii-cho 465, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, 602-8566, Japan. nakamae@koto.kpu-m.ac.jp

Journal of Psychiatric Research
|October 23, 2010
PubMed
Summary

This study found reduced white matter integrity in the corpus callosum of patients with obsessive-compulsive disorder (OCD). These findings in drug-free individuals highlight potential white matter abnormalities in OCD pathophysiology.

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Area of Science:

  • Neuroimaging
  • Neurology
  • Psychiatry

Background:

  • Increasing evidence suggests white matter abnormalities in obsessive-compulsive disorder (OCD).
  • Previous diffusion tensor imaging (DTI) studies yielded inconsistent results due to methodological limitations and small samples of drug-free patients.

Purpose of the Study:

  • To investigate white matter abnormalities in a large sample of drug-free OCD patients.
  • To utilize advanced DTI and tract-based spatial statistics (TBSS) to overcome previous methodological issues.

Main Methods:

  • Diffusion tensor imaging (DTI) was performed on 30 drug-free patients with OCD and 30 healthy controls.
  • Tract-based spatial statistics (TBSS) was used for voxel-wise group comparison of white matter fractional anisotropy (FA).
  • Fourteen of the OCD patients were drug-naïve.

Main Results:

  • OCD patients exhibited significantly lower FA in the anterior body of the corpus callosum (CC) compared to controls.
  • A trend towards lower FA was observed in the corpus callosum, right cingulum, and left anterior limb of the internal capsule (ALIC) in OCD patients.
  • No brain regions showed significantly higher FA in OCD patients.

Conclusions:

  • This is the first DTI-TBSS study of white matter abnormalities in non-medicated OCD patients.
  • Microstructural white matter alterations in the CC, cingulum, and ALIC may play a role in the pathophysiology of OCD.