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Published on: January 31, 2020
[T cell receptor constant alpha chain gene +1592C/T polymorphism may not be associated with IgA nephropathy]
Shi-liang Li1, Xu Lin, Jie Wang
1Department of Nephrology, Affiliated Hospital, Youjiang Medical University for Nationalities, Baise 533000, China. lishiliang-6605850@163.com
Objective:
To investigate the relationship between T cell receptor constant alpha chain (TCRCα) gene +1592C/T polymorphism and IgA nephropathy.
Methods:
TCRCα +1592C/T genotypes were identified by PCR-RFLP and direct sequencing in 244 Chinese Han patients with IgA nephropathy, who were classified according to their genotype into CC (188 cases), CT (54 cases) and TT (2 cases) groups. The clinical and pathological data of the patients were analyzed in relation to the TCRCα +1592C/T genotypes.
Results:
No significant differences in the clinical and biochemical indices were found in these patients with different TCRCα gene +1592C/T genotypes. TCRCα +1592C/T polymorphism was not found to contribute to severity or manifestations of renal pathology.
Conclusions:
TCRCα+1592C/T polymorphism may not be associated with the susceptibility to IgA nephropathy in the Chinese Han population.
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