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Related Concept Videos

Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

Modified-Release Drug Delivery Systems: Stimuli-Activated

Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...
Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

Modified-Release Drug Delivery Systems: Rate-Programmed II

Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
Modified-Release Drug Delivery Systems: Rate-Programmed I01:22

Modified-Release Drug Delivery Systems: Rate-Programmed I

Rate-programmed drug delivery systems (DDS) are designed to release drugs at specific, controlled rates to maintain consistent therapeutic levels. These systems are categorized based on their release mechanisms, including dissolution-controlled DDS, diffusion-controlled DDS, and combined dissolution-diffusion-controlled DDS.In dissolution-controlled DDS, the release rate depends on the slow dissolution of the drug itself or the surrounding matrix. Drugs with inherently slow dissolution rates,...
Modified-Release Drug Delivery Systems: Classification01:23

Modified-Release Drug Delivery Systems: Classification

Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.

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Updated: Jun 7, 2026

Preparation of Multifunctional Silk-Based Microcapsules Loaded with DNA Plasmids Encoding RNA Aptamers and Riboswitches
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Published on: October 8, 2021

Stimuli-responsive controlled-release system using quadruplex DNA-capped silica nanocontainers.

Cuie Chen1, Fang Pu, Zhenzhen Huang

  • 1Laboratory of Chemical Biology and State Key laboratory of Rare Earth Resources Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, PR China.

Nucleic Acids Research
|October 23, 2010
PubMed
Summary

Researchers developed a novel pH-responsive DNA-capped mesoporous silica nanoparticle system for controlled and reversible molecular delivery. This smart nanocarrier system offers precise control over cargo release, paving the way for advanced drug delivery applications.

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Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization

Published on: January 24, 2025

Area of Science:

  • Nanotechnology
  • Biomaterials Science
  • Molecular Engineering

Background:

  • Controlled cargo release is crucial for targeted therapies and advanced material applications.
  • Existing delivery systems often lack precise environmental responsiveness and reversibility.
  • Mesoporous silica nanoparticles (MSNs) offer high surface area and tunable pore sizes for encapsulation.

Purpose of the Study:

  • To develop a novel, pH-responsive, and reversible molecular gate-like delivery system.
  • To utilize i-motif quadruplex DNA as smart caps for MSNs, enabling controlled cargo release.
  • To demonstrate the potential for on-demand molecular transport and versatile nanodevice applications.

Main Methods:

  • Construction of mesoporous silica nanoparticles functionalized with i-motif quadruplex DNA caps.
  • Investigation of pH-induced conformational changes in i-motif DNA for pore opening and closing.
  • Demonstration of reversible cargo release and partial delivery control.
  • Development of a pH-switchable nanoreactor to validate the delivery system.

Main Results:

  • Successful construction of a proton-fueled molecular gate-like delivery system using i-motif DNA-capped MSNs.
  • Demonstrated smart, reversible opening and closing of the pore system in response to pH stimuli.
  • Achieved controlled and on-demand partial cargo delivery.
  • Validated the system's potential for molecular transport through a pH-switchable nanoreactor.

Conclusions:

  • The developed i-motif DNA-capped MSN system provides a novel platform for controlled and reversible molecular delivery.
  • This pH-responsive system offers precise control over cargo release, applicable to nanoreactors and drug delivery.
  • The approach opens new avenues for utilizing functional nucleic acids as capping agents in advanced nanodevices.