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Bacterial infection causes stress-induced memory dysfunction in mice.

Mélanie G Gareau1, Eytan Wine, David M Rodrigues

  • 1Cell Biology Program, Research Institute, Hospital for Sick Children, Toronto, ON, Canada. philip.sherman@sickkids.ca

Gut
|October 23, 2010
PubMed
Summary

The gut microbiota impacts memory formation. Bacterial infections combined with stress impair memory, but probiotics can help. Germ-free mice show baseline memory deficits, highlighting the microbiota's crucial role.

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Area of Science:

  • Neuroscience
  • Microbiology
  • Gastroenterology

Background:

  • The brain-gut axis links psychological stress to gut function and behavior.
  • The reciprocal influence of gut events, like infections, on stress-related behavior is unclear.

Purpose of the Study:

  • To investigate how enteric infection or absence of gut microbiota affects anxiety and memory.
  • To assess the impact of stress on behavior in infected and germ-free mice.

Main Methods:

  • Assessed behavior in Citrobacter rodentium-infected and germ-free mice, with or without acute stress.
  • Evaluated probiotic treatment for normalizing behavior and explored mechanisms.

Main Results:

  • Infection alone did not cause behavioral changes, but stress induced memory dysfunction in infected mice.
  • Probiotic treatment prevented memory deficits in infected mice.
  • Germ-free mice exhibited impaired memory regardless of stress exposure.

Conclusions:

  • The intestinal microbiota is essential for memory formation.
  • Stress exacerbates memory dysfunction in infected mice, while its absence alters baseline memory.