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Cryptococcal Meningitis

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Sexually Transmitted Infections01:26

Sexually Transmitted Infections

Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
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Related Experiment Video

Updated: Jun 7, 2026

Passive Administration of Monoclonal Antibodies Against H. capsulatum and Others Fungal Pathogens
09:57

Passive Administration of Monoclonal Antibodies Against H. capsulatum and Others Fungal Pathogens

Published on: February 14, 2011

Cutaneous histoplasmosis in AIDS.

C Chande1, S Menon, A Gohil

  • 1Department of Microbiology, Grant Medical College & Sir J. J. Hospital, Mumbai, India. cachande@gmail.com

Indian Journal of Medical Microbiology
|October 23, 2010
PubMed
Summary

This study details a human immunodeficiency virus (HIV) patient with disseminated histoplasmosis. Antifungal treatment showed initial success, but relapsed disease highlights challenges in managing this opportunistic infection in immunocompromised individuals.

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Last Updated: Jun 7, 2026

Passive Administration of Monoclonal Antibodies Against H. capsulatum and Others Fungal Pathogens
09:57

Passive Administration of Monoclonal Antibodies Against H. capsulatum and Others Fungal Pathogens

Published on: February 14, 2011

Area of Science:

  • Mycology
  • Infectious Diseases
  • Immunology

Background:

  • Disseminated histoplasmosis is a severe opportunistic infection in patients with advanced human immunodeficiency virus (HIV).
  • Early diagnosis and treatment are crucial for managing Histoplasma capsulatum infections in immunocompromised populations.

Observation:

  • A patient with HIV presented with widespread skin lesions and oral ulcers.
  • Cultures confirmed Histoplasma capsulatum in both cutaneous and oral mucosal scrapings.
  • The patient experienced initial improvement with Amphotericin B and itraconazole.

Findings:

  • Lesions recurred after three months, coinciding with a decline in CD4 counts, indicating immune deterioration.
  • The recurrence of disseminated histoplasmosis underscores the challenges in achieving sustained remission in severely immunocompromised patients.
  • Retreatment with the same regimen was initiated, and the patient remains under ongoing clinical observation.

Implications:

  • This case highlights the critical role of immune status in the management of disseminated fungal infections in HIV patients.
  • Relapse of histoplasmosis necessitates vigilant monitoring of treatment response and immune markers (CD4 counts).
  • Further research into optimizing long-term antifungal strategies for HIV-associated histoplasmosis is warranted.