Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Phospholipases, enzymes that share a substrate class.

M Waite1

  • 1Department of Biochemistry, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, North Carolina 27103.

Advances in Experimental Medicine and Biology
|January 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Two-minute versus 6-minute walk distances during 6-minute walk test in neuromuscular disease: Is the 2-minute walk test an effective alternative to a 6-minute walk test?

European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society·2018
Same author

Dynamics of microglial activation: a confocal time-lapse analysis in hippocampal slices.

Glia·2001
Same author

Chronic caloric restriction alters muscle membrane fatty acid content.

Experimental gerontology·2000
Same author

Concepts in imaging and microscopy. Exploring biological structure and function with confocal microscopy.

The Biological bulletin·1999
Same author

The PLD superfamily: insights into catalysis.

Biochimica et biophysica acta·1999
Same author

Confocal imaging of microglial cell dynamics in hippocampal slice cultures.

Methods (San Diego, Calif.)·1999

Researchers are discovering new phospholipases (PLs) faster than they can study them. Understanding these enzymes at a molecular level is crucial for appreciating their unique functions and regulatory mechanisms in situ.

Area of Science:

  • Biochemistry
  • Enzymology
  • Molecular Biology

Background:

  • Phospholipases (PLs) have been studied for nearly a century, with intensified research since the mid-1970s due to their recognized roles in signal transduction and pathophysiology.
  • Significant progress has been made in understanding PLs at molecular and mechanistic levels.
  • The discovery rate of new PLs currently outpaces the capacity for detailed functional and mechanistic studies.

Purpose of the Study:

  • To highlight the disparity between the discovery of new phospholipases and the in-depth study of their unique functions.
  • To emphasize the importance of understanding phospholipase (PL) molecular mechanisms, substrate interactions, and in situ regulation.

Main Methods:

  • Literature review and synthesis of existing research on phospholipase discovery and characterization.

Related Experiment Videos

  • Analysis of the current challenges in studying newly identified phospholipases.
  • Conceptual framework for prioritizing detailed molecular investigations.

    • Main Results:

    • The discovery of novel phospholipases continues at an accelerated pace.
    • There is a critical need to deepen the understanding of individual phospholipase (PL) molecular functions.
    • Current research capacity struggles to keep pace with the rate of new phospholipase identification.

    Conclusions:

    • A concerted effort is required to bridge the knowledge gap between phospholipase (PL) discovery and detailed molecular understanding.
    • Focusing on molecular-level interactions and regulatory mechanisms is essential for elucidating the roles of both known and newly discovered PLs.
    • Future research should prioritize in situ functional and regulatory studies of phospholipases (PLs) to fully appreciate their biological significance.