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Updated: Jun 7, 2026
In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography
Published on: July 24, 2020
Intraoperative spectral domain optical coherence tomography for vitreoretinal surgery
Yuankai K Tao1, Justis P Ehlers, Cynthia A Toth
1Department of Biomedical Engineering, Duke University, 136 Hudson Hall, Durham, North Carolina 27708, USA. yt13@duke.edu
Abstract:
We demonstrate in vivo human retinal imaging using an intraoperative microscope-mounted optical coherence tomography system (MMOCT). Our optomechanical design adapts an Oculus Binocular Indirect Ophthalmo Microscope (BIOM3), suspended from a Leica ophthalmic surgical microscope, with spectral domain optical coherence tomography (SD-OCT) scanning and relay optics. The MMOCT enables wide-field noncontact real-time cross-sectional imaging of retinal structure, allowing for SD-OCT augmented intrasurgical microscopy for intraocular visualization. We experimentally quantify the axial and lateral resolution of the MMOCT and demonstrate fundus imaging at a 20Hz frame rate.
