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Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates
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Published on: September 5, 2017

Characteristics and programme-defined treatment outcomes among childhood tuberculosis (TB) patients under the

Srinath Satyanarayana1, Roopa Shivashankar, Ram Pal Vashist

  • 1Centre for Operational Research, International Union against Tuberculosis and Lung Diseases (The Union), Paris, France. ssrinath@theunion.org

Plos One
|October 23, 2010
PubMed

Insights

Childhood tuberculosis treatment in India shows high completion rates (95%) despite some patients receiving lower drug doses than WHO guidelines. Further studies are needed to optimize care for pediatric TB patients.

Area of Science:

  • Pediatric Infectious Diseases
  • Public Health Interventions
  • Tuberculosis Control

Background:

  • Childhood tuberculosis (TB) management in India follows the Revised National TB Control Programme (RNTCP) using specific diagnostic and treatment protocols.
  • Current RNTCP weight-band based dosing may result in sub-optimal anti-TB drug doses for some pediatric patients compared to WHO recommendations.

Purpose of the Study:

  • To describe baseline characteristics and treatment outcomes of childhood TB patients registered under RNTCP in Delhi.
  • To compare treatment completion rates between children receiving WHO-recommended doses versus those receiving lower doses.

Main Methods:

  • A cross-sectional retrospective study analyzing program records of 1089 children (<15 years) treated for TB in Delhi from January to June 2008.
  • Utilized RNTCP's adherence to WHO disease classification and treatment outcome definitions.

Main Results:

  • Of 1074 patients, 61% were female, 11% were under 5 years, 93% were new cases, and 63% had extra-pulmonary TB.
  • The overall reported treatment completion rate was 95%, with similar rates across subgroups, including those receiving lower drug doses.

Conclusions:

  • The RNTCP demonstrates high treatment completion rates for childhood TB in Delhi, even with some deviations from WHO-recommended drug dosages.
  • Further research is recommended to investigate low case notifications in young children, improve RNTCP reach, and validate diagnostic accuracy and treatment completion definitions.
Abstract

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