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Reconstructing the differentiation niche of embryonic stem cells using biomaterials

Laura E Dickinson1, Sravanti Kusuma, Sharon Gerecht

  • 1Department of Chemical and Biomolecular Engineering, Johns Hopkins Physical Sciences-Oncology Center and Institute for NanoBioTechnology, 3400 North Charles Street, Baltimore, MD 21210, USA.

Macromolecular Bioscience
|October 23, 2010
PubMed

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The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...