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Synthesis of N-substituted 3'-amino-3'-deoxythymidines and their biological evaluation against HIV
M S Motawia1, E B Pedersen, C M Nielsen
1Department of Chemistry, Odense University, Denmark.
Archiv Der Pharmazie
|December 1, 1990
Abstract:
Treatment of 3'-amino-3'-deoxythymidine (1) with carboxylic acid anhydrides afforded the corresponding acylamino derivatives 2a-f. Reaction of 1 with a variety of isothiocyanates led to the corresponding thioureido derivatives 3a-i. Also, conversion of 1 into 3'-carbylamino-3'-deoxythymidine (7) is reported. The compounds 2, 3, and 8 were evaluated for their anti-HIV activity in MT-4 cells, but did not show sufficient efficacy.