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Updated: Jun 7, 2026
Orthotopic Ovarian Transplantation Procedures to Investigate the Life- and Health-span Influence of Ovarian Senescence in Female Mice
Published on: February 12, 2018
[The effect of initial hormonal status of recipient animals on morphological state and endocrine function of ovarian
Abstract:
The aim of investigation was a comparative analysis of morphofunctional characteristics of allografts of mature ovarian tissue and neonatal ovary depending on initial hormonal status of recipient animals. Rats' mature ovarian tissue and neonatal ovary were transplanted under renal capsule simultaneously with ovariectomy and 2 months later. Data analysis indicated that the development of ovarian tissue transplant was determined by its maturity and initial hormonal status of recipient. Mature ovarian tissue transplants preserve morphology and endocrine function to the 60th day after transplantation to the recipient animals with the initial hormonal status that corresponds to the norm. Neonatal ovary transplants are developed to the mature stage following transplantation to recipients with hormonal status that corresponded to the ovariectomized animals, that is, low concentration of sex hormones and an increased level of follicle-stimulating hormone.
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