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Identification of Intracellular Signaling Events Induced in Viable Cells by Interaction with Neighboring Cells Undergoing Apoptotic Cell Death
09:18

Identification of Intracellular Signaling Events Induced in Viable Cells by Interaction with Neighboring Cells Undergoing Apoptotic Cell Death

Published on: December 27, 2016

Apoptosis signaling kinases: from stress response to health outcomes

Kohsuke Takeda1, Isao Naguro, Hideki Nishitoh

  • 1Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, Strategic Approach to Drug Discovery and Development in Pharmaceutical Sciences, Global Center of Excellence Program and Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, The University of Tokyo, Tokyo, Japan. takeda@mol.f.u-tokyo.ac.jp

Antioxidants & Redox Signaling
|October 26, 2010
PubMed

Insights

This review details apoptosis signaling kinases, crucial regulators of cellular stress responses and apoptosis. Dysregulation of these kinases impacts health outcomes, highlighting their broader physiological roles.

Area of Science:

  • Cellular Biology
  • Molecular Biology
  • Biochemistry

Background:

  • Apoptosis is a regulated process vital for multicellular organism development and homeostasis.
  • Caspases and Bcl-2 family proteins are key regulators of apoptosis.
  • Protein kinases also regulate apoptosis sensitivity and cellular stress responses.

Purpose of the Study:

  • To catalog apoptosis signaling kinases involved in cellular stress responses.
  • To discuss the roles of these kinases in stress responses.
  • To emphasize health outcomes associated with kinase dysregulation.

Main Methods:

  • Literature review of apoptosis signaling kinases.
  • Analysis of kinase roles in diverse cellular stress responses.
  • Focus on kinase-induced apoptosis and health implications.

Main Results:

  • Apoptosis signaling kinases regulate diverse cellular responses beyond apoptosis.
  • These kinases act at multiple steps in apoptosis pathways.
  • Dysregulation of these kinases has significant health consequences.

Conclusions:

  • Apoptosis signaling kinases are critical regulators of cellular stress responses.
  • Understanding their roles is essential for addressing health outcomes.
  • Further research into these kinases can reveal therapeutic targets.

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