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Updated: Jun 7, 2026
Measuring Diurnal Rhythms in Autophagic and Proteasomal Flux
Published on: September 17, 2019
24-hour temporal pattern of NTPDase and 5'-nucleotidase enzymes in rat blood serum
Bernardo Carraro Detanico1, Andressa de Souza, Liciane Fernandes Medeiros
1Departamento de Farmacologia, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Rua Sarmento Leite 500, Porto Alegre, Brazil.
Abstract:
Circadian rhythms represent an important mechanism to prepare the organism for environmental variations. ATP, ADP, AMP, and adenosine can act as extracellular messengers in a range of biological processes and are metabolized by a number of enzymes, including NTPDases and 5'-nucleotidase. In the present study the authors report that ATPase and ADPase activities present 24-h temporal variations that peak during dark (activity) span. These findings suggest that this enzymatic temporal pattern in blood serum might be important for the normal physiology and function of the organism through the maintenance of extracellular nucleotides at physiological levels.
