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Related Experiment Video

Updated: Jun 7, 2026

Horizontal Hippocampal Slices of the Mouse Brain

Horizontal Hippocampal Slices of the Mouse Brain

Published on: September 22, 2020

Why avoid the hippocampus? A comprehensive review.

Vinai Gondi¹, Wolfgang A Tomé, Minesh P Mehta

¹Department of Human Oncology, University of Wisconsin Comprehensive Cancer Center, Madison, WI 53792, USA. gondi@humonc.wisc.edu

Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology

|October 26, 2010

Summary

This summary is machine-generated.

Modern IMRT techniques can spare the hippocampus subgranular zone during cranial irradiation. This may prevent radiation-induced neurocognitive decline, particularly memory impairment, in patients undergoing brain radiotherapy.

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Preparation of Acute Slices from Dorsal Hippocampus for Whole-Cell Recording and Neuronal Reconstruction in the Dentate Gyrus of Adult Mice

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Published on: April 3, 2021

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Last Updated: Jun 7, 2026

Horizontal Hippocampal Slices of the Mouse Brain

Horizontal Hippocampal Slices of the Mouse Brain

Published on: September 22, 2020

Preparation of Acute Slices from Dorsal Hippocampus for Whole-Cell Recording and Neuronal Reconstruction in the Dentate Gyrus of Adult Mice

Preparation of Acute Slices from Dorsal Hippocampus for Whole-Cell Recording and Neuronal Reconstruction in the Dentate Gyrus of Adult Mice

Published on: April 3, 2021

Area of Science:

Radiation Oncology
Neuroscience
Neuro-oncology

Background:

Cranial irradiation can cause neurocognitive decline.
Damage to hippocampal neural progenitor cells is linked to memory deficits after radiation.
The subgranular zone of the hippocampus is critical for memory formation.

Purpose of the Study:

To review the rationale for sparing the hippocampus subgranular zone during cranial irradiation.
To discuss the link between subgranular zone damage and neurocognitive decline.
To present pilot data and introduce a clinical trial evaluating subgranular zone sparing.

Main Methods:

Literature review of neurocognitive effects of cranial irradiation.
Analysis of clinical and preclinical data on subgranular zone damage and memory.
Review of pilot studies on the feasibility of hippocampal subgranular zone sparing.

Main Results:

Hippocampal subgranular zone damage is associated with radiation-induced memory deficits.
Pilot investigations suggest feasibility of sparing the subgranular zone during whole-brain radiotherapy.
A Phase II clinical trial (RTOG 0933) is evaluating the neurocognitive benefits of this technique.

Conclusions:

Sparing the subgranular zone of the hippocampus is a promising strategy to mitigate radiation-induced neurocognitive decline.
Further prospective evaluation through clinical trials is necessary to confirm these benefits.
This approach may improve long-term quality of life for brain tumor patients.