Determination of free and total bisphenol A in urine of infants
Wolfgang Völkel1, Mandy Kiranoglu, Hermann Fromme
1Bavarian Health and Food Safety Authority, Environmental Medicine/Biomonitoring, Munich, Germany. Wolfgang.Voelkel@lgl.bayern.de
Environmental Research
|October 26, 2010
Abstract:
Infants may be particularly sensitive regarding hormonally active compounds such as Bisphenol A (BPA), which is widely distributed and exhibits weak oestrogenic activity. Since only free (unconjugated) BPA exhibits endocrine activity, both free and total (after hydrolysis of conjugates) BPA were determined in urine samples of infants to support valid risk assessments. Free BPA was observed above the LOQ in only 3 of 91 (3%) samples from 47 infants. As total BPA was observed in only 38 (42%) urine samples, with concentrations between
