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Related Concept Videos

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Related Experiment Video

Updated: Jun 7, 2026

Measurement of the Hepatic Venous Pressure Gradient and Transjugular Liver Biopsy
07:10

Measurement of the Hepatic Venous Pressure Gradient and Transjugular Liver Biopsy

Published on: June 18, 2020

Prokinetics in acute upper GI bleeding: a meta-analysis.

Alan N Barkun1, Marc Bardou, Myriam Martel

  • 1Division of Gastroenterology, McGill University Health Center, McGill University, Montreal, Quebec, Canada.

Gastrointestinal Endoscopy
|October 26, 2010
PubMed
Summary
This summary is machine-generated.

Prokinetic agents like erythromycin before endoscopy may reduce repeat procedures for acute upper GI bleeding. However, these agents did not significantly impact blood transfusions, hospital stays, or surgery needs in this meta-analysis.

Related Experiment Videos

Last Updated: Jun 7, 2026

Measurement of the Hepatic Venous Pressure Gradient and Transjugular Liver Biopsy
07:10

Measurement of the Hepatic Venous Pressure Gradient and Transjugular Liver Biopsy

Published on: June 18, 2020

Area of Science:

  • Gastroenterology
  • Clinical Medicine
  • Pharmacology

Background:

  • Emerging data suggest prokinetics administered before gastroscopy may benefit patients with acute upper GI bleeding (UGIB).
  • Existing studies evaluating prokinetics for UGIB are limited by small sample sizes and conflicting conclusions.

Purpose of the Study:

  • To systematically evaluate the evidence regarding the efficacy of prokinetic agents administered prior to esophagogastroduodenoscopy (EGD) in patients with acute UGIB.

Main Methods:

  • A meta-analysis was conducted on randomized controlled trials identified through comprehensive literature searches from 1990 to January 2010.
  • The primary outcome assessed was the necessity for repeat EGD, with secondary outcomes including endoscopic visualization, blood transfusion requirements, hospitalization duration, and surgical intervention.
  • Data were analyzed using odds ratios (ORs) and weighted mean differences (WMDs).

Main Results:

  • Three full articles and two abstracts, encompassing 316 patients, were included in the meta-analysis.
  • Prokinetic agents (erythromycin or metoclopramide) significantly decreased the need for repeat EGD (OR 0.55; 95% CI, 0.32-0.94).
  • No significant differences were observed in blood transfusions (WMD, -0.40; 95% CI, -0.86 to 0.06), hospital stay (WMD, -1.04; 95% CI, -2.83 to 0.76), or surgery rates (OR 1.11; 95% CI, 0.27-4.67).

Conclusions:

  • The meta-analysis indicates that intravenous erythromycin or metoclopramide before EGD in acute UGIB patients reduces the requirement for repeat procedures.
  • The study's findings are constrained by the limited number of patients included in the analyzed trials.
  • Prokinetic administration did not demonstrate improvement in other key clinical outcomes such as transfusion needs, length of hospital stay, or surgical intervention.