Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jun 7, 2026

Social Defeat Stress Model for Adolescent C57BL/6 Male and Female Mice
07:15

Social Defeat Stress Model for Adolescent C57BL/6 Male and Female Mice

Published on: March 15, 2024

Modeling fighting deprivation effect in mouse repeated aggression paradigm.

Natalia N Kudryavtseva1, Dmitry A Smagin, Natalia P Bondar

  • 1Neurogenetics of Social Behavior Sector, Institute of Cytology and Genetics, SD RAS, Acad Lavrentjev Avenue 10, Novosibirsk 630090, Russia. n.n.kudryavtseva@gmail.com

Progress in Neuro-Psychopharmacology & Biological Psychiatry
|October 26, 2010
PubMed
Summary

Male mice with a history of winning fights develop increased aggression after a no-fight period. Fighting deprivation, not other rewards, appears to be the primary trigger for this enhanced aggressive behavior.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Neurotransmitter Genes in the Nucleus Accumbens That Are Involved in the Development of a Behavioral Pathology After Positive Fighting Experiences and Their Deprivation: A Conceptual Paradigm for Data Analysis.

International journal of molecular sciences·2025
Same author

Blood Plasma Markers in Depressed Mice under Chronic Social Defeat Stress.

Biomedicines·2024
Same author

Th17 Cells, Glucocorticoid Resistance, and Depression.

Cells·2023
Same author

Unraveling the Unusual Subgenomic Organization in the Neopolyploid Free-Living Flatworm Macrostomum lignano.

Molecular biology and evolution·2023
Same author

Effects of Positive Fighting Experience and Its Subsequent Deprivation on the Expression Profile of Mouse Hippocampal Genes Associated with Neurogenesis.

International journal of molecular sciences·2023
Same author

Once induced, it lasts for a long time: the structural and molecular signatures associated with depressive-like behavior after neonatal immune activation.

Frontiers in cellular neuroscience·2023

Area of Science:

  • Neuroscience
  • Behavioral Science
  • Animal Models

Background:

  • Repeated aggressive encounters in male mice lead to behavioral psychopathology.
  • Winning these encounters establishes a history of aggression and victory.

Purpose of the Study:

  • To investigate the effects of fighting deprivation on aggression in male mice with a winning history.
  • To determine if natural hedonic stimuli influence aggression following fighting deprivation.

Main Methods:

  • Male mice with a documented history of winning (20 consecutive victories) were subjected to a no-fight period.
  • Aggression levels were measured before and after the fighting deprivation period.
  • The impact of hedonic stimuli (females, sweet water) during deprivation was assessed.

More Related Videos

A Multiple Integrated Social Stress Model for Psychiatric Disorders in Female C57BL/6J Mice
06:15

A Multiple Integrated Social Stress Model for Psychiatric Disorders in Female C57BL/6J Mice

Published on: July 15, 2025

Chronic Social Defeat Stress in Early Adolescent Male Mice
07:06

Chronic Social Defeat Stress in Early Adolescent Male Mice

Published on: January 24, 2025

Related Experiment Videos

Last Updated: Jun 7, 2026

Social Defeat Stress Model for Adolescent C57BL/6 Male and Female Mice
07:15

Social Defeat Stress Model for Adolescent C57BL/6 Male and Female Mice

Published on: March 15, 2024

A Multiple Integrated Social Stress Model for Psychiatric Disorders in Female C57BL/6J Mice
06:15

A Multiple Integrated Social Stress Model for Psychiatric Disorders in Female C57BL/6J Mice

Published on: July 15, 2025

Chronic Social Defeat Stress in Early Adolescent Male Mice
07:06

Chronic Social Defeat Stress in Early Adolescent Male Mice

Published on: January 24, 2025

Main Results:

  • Mice exhibited enhanced aggression after the no-fight period compared to baseline levels.
  • Fighting deprivation itself, rather than hedonic stimuli, was the primary factor in increasing aggression.
  • Aberrant behaviors were observed, linked to the experience of repeated aggression and victories.

Conclusions:

  • Fighting deprivation is a significant stimulus for elevated aggression in male mice with a history of winning.
  • This phenomenon may be a useful model for studying the effects of social isolation and deprivation in aggression paradigms.
  • The findings highlight the complex interplay between experience, deprivation, and behavioral outcomes in aggression.