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Updated: Jun 7, 2026

15N CPMG Relaxation Dispersion for the Investigation of Protein Conformational Dynamics on the µs-ms Timescale
Published on: April 19, 2021
RECORD processing - a robust pathway to component-resolved HR-PGSE NMR diffusometry
1Physical Chemistry and Industrial NMR Centre, Royal Institute of Technology (KTH), Teknikringen 36, SE-100 44 Stockholm, Sweden. peter@physchem.kth.se
Abstract:
It is demonstrated that very robust spectral component separation can be achieved through global least-squares CORE data analysis of automatically or manually selected spectral regions in complex NMR spectra in a high-resolution situation. This procedure (acronym RECORD) only takes a few seconds and quite significantly improves the effective signal/noise of the experiment as compared to individual frequency channel fitting, like in the generic HR-DOSY approach or when using basic peak height or integral fitting. Results from RECORD processing can be further used as starting value estimates for subsequent CORE analysis of spectral data with higher degree of spectral overlap.
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