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Updated: Jun 7, 2026

An Ex Vivo Porcine Model for Hydrodynamic Testing of Experimental Aortic Valve Procedures and Novel Medical Devices
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An Ex Vivo Porcine Model for Hydrodynamic Testing of Experimental Aortic Valve Procedures and Novel Medical Devices

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Prosthetic aortic heart valves: modeling and design.

Hadi Mohammadi1, Kibret Mequanint

  • 1The Human Performance Laboratory, Faculty of Kinesiology, University of Calgary, Calgary, Alberta, Canada. hadim74@gmail.com

Medical Engineering & Physics
|October 26, 2010
PubMed
Summary

This review explores polymer-based trileaflet mechanical heart valves (MHVs) to improve cardiovascular surgery outcomes. Mimicking natural valve geometry and biomaterials offers a promising approach for enhanced prosthetic heart valve (HV) design.

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Area of Science:

  • Biomaterials Science
  • Mechanical Engineering
  • Cardiovascular Surgery

Background:

  • Heart valve replacement is a common cardiovascular procedure with unpredictable outcomes.
  • Prosthetic heart valve (HV) design and material selection are critical factors influencing success.
  • Current bileaflet mechanical heart valves (MHVs) show satisfactory performance but have room for improvement.

Purpose of the Study:

  • To review modeling techniques for prosthetic heart valve (HV) design.
  • To justify and propose the development of a polymer-based trileaflet mechanical heart valve (MHV).
  • To explore biomimicry of native aortic valve geometry and material properties for improved MHV design.

Main Methods:

  • Literature review of modeling techniques in prosthetic heart valve (HV) design.

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Last Updated: Jun 7, 2026

An Ex Vivo Porcine Model for Hydrodynamic Testing of Experimental Aortic Valve Procedures and Novel Medical Devices
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Published on: August 25, 2023

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  • Analysis of closing/opening phase behavior in bileaflet MHVs.
  • Discussion of potential failure modes, such as crack propagation in pyrolytic carbon leaflets.

    • Main Results:

    • Modeling techniques are valuable tools for prosthetic heart valve (HV) design.
    • Bileaflet MHVs exhibit satisfactory performance but have limitations.
    • Pyrolytic carbon leaflets may be prone to crack propagation, indicating a need for material improvement.

    Conclusions:

    • There is a clear justification for improving mechanical heart valve (MHV) design.
    • Mimicking the trileaflet structure and anisotropic, hyperelastic properties of native aortic valves is a promising strategy.
    • Polymer-based trileaflet MHVs offer a potential advancement in cardiovascular prosthetics.