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Related Experiment Videos

Life span differences in digoxin uptake and excretion.

T S Chen1, C L Wabner

  • 1Department of Pharmacology and Toxicology, University of Louisville, KY 40292.

Experimental Gerontology
|January 1, 1990
PubMed
Summary
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Aging alters how the body processes digoxin. Myocardial uptake increases, while renal excretion decreases in older animals, potentially explaining age-related digitalis sensitivity.

Area of Science:

  • Pharmacology
  • Gerontology
  • Physiology

Background:

  • Age-related changes in drug metabolism are not well understood.
  • Digitalis susceptibility varies with age, but mechanisms are unclear.

Purpose of the Study:

  • To investigate age-dependent changes in digoxin uptake and excretion in rodents.
  • To elucidate the physiological mechanisms behind altered digitalis sensitivity in aging.

Main Methods:

  • Studied digoxin uptake in cardiac and renal cortical slices from mice and rats across different life stages (growth, maturity, aging).
  • Analyzed kinetic parameters (Km, Vmax) for myocardial uptake.
  • Assessed renal clearance and tubular secretory capacity for digoxin.

Main Results:

Related Experiment Videos

  • Myocardial digoxin uptake increased significantly with senescence.
  • Renal uptake was highest during growth, declining with age.
  • Renal clearance and secretory capacity decreased significantly in aging animals.

Conclusions:

  • Digoxin clearance and tubular activity increase during growth.
  • Myocardial uptake of digoxin rises, while renal excretion falls during aging.
  • These age-related pharmacokinetic shifts may explain altered digitalis susceptibility in the elderly.