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Related Experiment Video

Updated: Apr 29, 2026

Non-enzymatic, Serum-free Tissue Culture of Pre-invasive Breast Lesions for Spontaneous Generation of Mammospheres
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Perspectives on margins in DCIS: pathology.

Susan Lester1

  • 1Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.

Journal of the National Comprehensive Cancer Network : JNCCN
|October 26, 2010
PubMed
Summary

Ductal carcinoma in situ (DCIS) may not always progress to invasive breast cancer. Residual disease after treatment is hard to predict, and other factors influence patient survival.

Area of Science:

  • Oncology
  • Pathology
  • Breast Cancer Research

Background:

  • Breast carcinomas originate from the ductal/lobular system as carcinoma in situ (CIS).
  • Only a subset of CIS lesions progress to invasive carcinoma.
  • Pathologic evaluation of CIS extent and margins estimates residual disease but lacks certainty.

Purpose of the Study:

  • To explore factors influencing breast cancer survival beyond residual disease in patients with DCIS.
  • To highlight the limitations of predicting residual disease solely based on surgical margins.

Main Methods:

  • Review of existing literature on ductal carcinoma in situ (DCIS) progression and breast cancer outcomes.
  • Analysis of factors contributing to patient survival in DCIS cases.
  • Pathologic evaluation of CIS extent, margin status, and stromal characteristics.

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Main Results:

  • Pathologic evaluation of DCIS extent and margin involvement provides an estimate, not a certainty, of residual disease.
  • Factors beyond residual disease, such as new ipsilateral or contralateral cancers, significantly impact survival.
  • Stromal resistance to invasion may play a role in patient outcomes.

Conclusions:

  • Predicting residual disease in DCIS is uncertain, even with thorough pathologic evaluation.
  • Patient survival in DCIS cases is influenced by multiple factors, including new primary tumors and stromal characteristics.
  • Further research is needed to fully understand the multifactorial nature of breast cancer progression and survival.