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Related Concept Videos

Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Neuroplasticity01:01

Neuroplasticity

Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.
Gene-Environment Interactions01:20

Gene-Environment Interactions

Gene expression is a dynamic process that is significantly influenced by environmental factors. This interaction underlies the complex nature of biological development and the phenotypic differences observed among individuals, even among those with identical genetic makeups. Factors such as radiation, temperature, behavior, nutrition, and stress play pivotal roles in determining how genes are expressed. The concept of the reaction range is central to understanding this interaction. It posits...
Human Genetics01:28

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...

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Related Experiment Video

Updated: Jun 7, 2026

Optimized Analysis of DNA Methylation and Gene Expression from Small, Anatomically-defined Areas of the Brain
13:11

Optimized Analysis of DNA Methylation and Gene Expression from Small, Anatomically-defined Areas of the Brain

Published on: July 12, 2012

Child health, developmental plasticity, and epigenetic programming.

Z Hochberg1, R Feil, M Constancia

  • 1Rambam Medical Center, Rappaport Faculty of Medicine and Research Institute, Technion–Israel Institute of Technology, Haifa, Israel. z_hochberg@rambam.health.gov.il

Endocrine Reviews
|October 26, 2010
PubMed
Summary
This summary is machine-generated.

Early life experiences shape long-term health through developmental plasticity and epigenetic changes. These modifications, influenced by environmental cues, can impact gene expression and potentially be passed to future generations.

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Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
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Last Updated: Jun 7, 2026

Optimized Analysis of DNA Methylation and Gene Expression from Small, Anatomically-defined Areas of the Brain
13:11

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Published on: July 12, 2012

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
19:15

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale

Published on: August 25, 2014

Area of Science:

  • Developmental biology
  • Epigenetics
  • Human health

Background:

  • Early life environmental exposures profoundly influence long-term health.
  • Developmental origins of health and disease (DOHaD) theories posit that early life cues set long-term biological strategies.
  • Life-history transitions are critical periods for these programming effects.

Purpose of the Study:

  • To explore the concept of developmental plasticity and its role in adapting to changing environments.
  • To examine the mechanisms by which early life experiences, including epigenetic responses, influence health trajectories.
  • To highlight the translational potential of epigenetic research in child health.

Main Methods:

  • Review of existing literature on developmental plasticity, DOHaD, and epigenetics.
  • Analysis of how environmental factors (placental, nutritional, endocrine) influence developmental programming.
  • Discussion of the translational research process from basic science to clinical applications.

Main Results:

  • Developmental plasticity, extending from preconception to early childhood, involves epigenetic modifications in response to environmental cues.
  • These epigenetic changes affect gene expression, development, sexual dimorphism, and can be transgenerationally transmitted.
  • Translational epigenetic research integrates basic, preclinical, and clinical studies.

Conclusions:

  • Identifying epigenetic consequences of fetal programming offers clinical applications.
  • Potential applications include epigenetic biomarkers for early disease diagnosis and identifying at-risk individuals.
  • Novel preventive and curative strategies based on diet and epigenetic drugs are foreseeable.