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Uptake of breast cancer prevention and screening trials

D Gareth Evans1, Michelle Harvie, Nigel Bundred

  • 1Genesis Prevention Centre, University Hospital of South Manchester NHS Trust, Manchester, UK. gareth.evans@cmft.nhs.uk

Journal of Medical Genetics
|October 26, 2010
PubMed
Abstract

Insights

Cancer prevention trial recruitment remains low globally. Improving trial designs and decision aids is crucial for prevention trials to be viable alternatives to surgery.

Area of Science:

  • Oncology
  • Clinical Trials
  • Preventive Medicine

Background:

  • Global uptake of cancer prevention trials is notably low.
  • This study addresses the disappointing participation rates in cancer prevention research.

Purpose of the Study:

  • To assess and compare recruitment rates for different types of cancer prevention trials.
  • To evaluate participation in chemotherapy and dietary prevention trials versus screening trials.

Main Methods:

  • Uptake data were collected for three randomized chemotherapy breast cancer prevention trials.
  • Two dietary prevention trials and screening trials were assessed in women with increased familial risk.
  • Comparison of uptake across various risk categories was performed.

Main Results:

  • Drug prevention trials showed low uptake (5.3-13.6%), with higher rates in high-risk groups (12%) versus very high-risk groups (8.4%).
  • Dietary prevention studies via mail recruitment had low uptake (6.2% and 12.5%).
  • Mammography screening trials achieved over 90% uptake across all risk categories.

Conclusions:

  • Significant improvements in recruitment for prevention trials are necessary for their viability.
  • Development of innovative trial designs and decision aids is essential to boost participation in prevention studies.

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