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Published on: September 20, 2019
Locally made ready to use therapeutic food for treatment of malnutrition a randomized controlled trial
Azara Sneha Singh1, Gagandeep Kang, Anup Ramachandran
1Departments of Gastrointestinal Sciences and Community Health, Christian Medical College, Vellore TN 632004, India.
Insights
A locally made ready-to-use therapeutic food (RUTF) significantly improved weight gain in children with mild to moderate malnutrition compared to standard care. This community-based intervention demonstrates RUTF
Area of Science:
- Nutritional Science
- Pediatric Health
- Public Health Interventions
Background:
- Malnutrition remains a significant global health challenge, particularly in developing regions.
- Early intervention is crucial for mitigating the long-term effects of malnutrition on child development.
- Effective and accessible therapeutic foods are essential for community-based treatment programs.
Purpose of the Study:
- To assess the efficacy of a locally produced ready-to-use therapeutic food (RUTF) in addressing mild to moderate malnutrition among young children.
- To compare the effectiveness of RUTF with the current standard of care in improving nutritional status.
Main Methods:
- A randomized, open-label, controlled trial was conducted in pre-schools in Vellore, India.
- Participants included children aged 18-60 months with a Weight-for-Age Z-score of -2 SD.
- Interventions involved either RUTF or a fortified cereal-milk supplement (High Calorie Cereal Milk - HCCM) for 3 months.
Main Results:
- Children receiving RUTF exhibited a statistically significant higher mean weight gain (0.54 kg) over 3 months compared to the HCCM group (0.38 kg).
- Weight gain per kilogram of body weight was found to be directly proportional to the initial severity of malnutrition.
- The study observed improvements in weight-for-age status in both intervention groups.
Conclusions:
- Community-based treatment for mild to moderate malnutrition resulted in weight gain in both RUTF and HCCM groups.
- Ready-to-use therapeutic food (RUTF) demonstrated superior effectiveness in promoting weight gain compared to the standard care (HCCM).
- These findings support the integration of locally produced RUTF into community health programs for improved child nutrition.
Objective:
To evaluate the effectiveness of a locally made ready-to-use therapeutic food (RUTF) in decreasing mild to moderate malnutrition.
Design:
A randomized open label, controlled trial.
Setting:
Pre-schools run by the Department of Community Health in Kaniyambadi administrative block, Vellore, India; duration of follow-up 3 months from the date of recruitment.
Participants:
Pupils aged 18 -60 months with Weight-for-Age 2 SD.
Interventions:
A locally produced energy-dense supplement (RUTF), and the current standard of care [teaching caregivers how to make a fortified cereal-milk supplement called High Calorie Cereal Milk (HCCM)].
Main Outcome Measures:
Increase in weight-for-age status; increase in levels of plasma zinc, vitamin B12, serum albumin and haemoglobin.
Results:
The Mean (SD) weight gain at 3 months was higher in the RUTF group: RUTF (n=51): 0.54 kg; (SE = 0.05; 95% CI = 0.44 - 0.65) vs HCCM (n=45): 0.38 kg;(SE = 0.06; 95% CI = 0.25 - 0.51), P = 0.047. The weight gain per kilogram of body weight was directly proportional to the severity of malnutrition.
Conclusions:
Community-based treatment showed weight gain in both groups, the gain being higher with RUTF.
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