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Clinical profile and outcome of swine flu in Indian children

Rashmi Ranjan Das1, Abdus Sami, Rakesh Lodha

  • 1Department of Pediatrics, All India Institute of Medical Sciences, New Delhi 110029, India.

Indian Pediatrics
|October 26, 2010
PubMed

Insights

This study details Indian children with 2009 H1N1 influenza, finding non-specific symptoms but identifying risk factors for hospitalization. Children with co-morbidities and specific symptoms faced higher risks, with some developing severe outcomes.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Virology

Background:

  • The 2009 H1N1 influenza pandemic posed a significant global health threat.
  • Understanding the clinical spectrum and outcomes in pediatric populations is crucial for effective management.
  • Limited data exists on the specific characteristics of H1N1 infection in Indian children.

Purpose of the Study:

  • To characterize the clinical presentation and outcomes of 2009 H1N1 influenza virus infection in Indian children.
  • To identify risk factors associated with severe disease and hospitalization in this pediatric cohort.

Main Methods:

  • A retrospective chart review was conducted on 85 Indian children diagnosed with 2009 H1N1 influenza.
  • Real-time reverse transcriptase polymerase chain reaction (RT-PCR) was used for diagnosis.
  • Clinical data, including symptoms, co-morbidities, treatment, and outcomes, were analyzed.

Main Results:

  • The majority of infected children (64.7%) were between 5 and 16 years old, with a mean age of 7.5 years.
  • Fever, cough, and rhinorrhea were the most common symptoms; 34% had underlying co-morbid conditions.
  • Hospitalization occurred in 35.3% of cases, with risk factors including co-morbidities, respiratory distress, and radiographic infiltrates. Three children developed Acute Respiratory Distress Syndrome (ARDS) and died.

Conclusions:

  • Clinical features of 2009 H1N1 influenza in children are often non-specific.
  • Children with co-morbidities, respiratory distress, vomiting, wheezing, diarrhea, hypotension, and radiographic infiltrates are at increased risk of hospitalization.
  • Prompt recognition of these risk factors is essential for timely intervention and improved outcomes in pediatric H1N1 cases.
Abstract

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