Intra-left ventricular systolic asynchrony in patients with overt hyperthyroidism.

Area of Science:

• Cardiology
• Endocrinology
• Medical Imaging

Background:

• Hyperthyroidism adversely affects cardiovascular function.
• Left ventricular (LV) asynchrony is characterized by desynchronized contraction of cardiac segments.
• Assessing LV asynchrony is crucial for understanding cardiovascular risks in hyperthyroid patients.

Purpose of the Study:

• To evaluate systolic asynchrony in patients diagnosed with overt hyperthyroidism.
• To compare LV asynchrony parameters between hyperthyroid patients and healthy controls.

Main Methods:

• Utilized tissue synchronization imaging (TSI) to assess cardiac function.
• Measured the time to regional peak systolic tissue velocity (Ts) in the LV using a six-basal-six-mid-segmental model.
• Computed four TSI parameters to quantify systolic asynchrony.

Main Results:

• All measured TSI parameters of LV asynchrony were significantly elevated in hyperthyroid patients compared to controls.
• Standard deviation of Ts for all 12 LV segments increased (35.7±14.4 vs 20.1±10.1, P<0.0001).
• Maximal difference in Ts between any two LV segments also showed significant increases.

Conclusions:

• Patients with overt hyperthyroidism exhibit evidence of left ventricular asynchrony.
• TSI is an effective method for detecting LV asynchrony in hyperthyroid individuals.
• LV asynchrony may contribute to the adverse cardiovascular effects of hyperthyroidism.