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Updated: Jun 7, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
Published on: December 11, 2017
The molecular fingerprint of cardiac dyssynchrony and cardiac resynchronization therapy
Marc Vanderheyden1, Chris Vrints, Jozef Bartunek
1Cardiovascular Center, Onze Lieve Vrouwziekenhuis, Aalst, Belgium. marc.vanderheyden@olvz-aalst.be
Abstract:
To date, cardiac resynchronization therapy remains the only treatment that enhances systolic function while improving long-term outcome and survival. Here, we review the molecular alterations associated with dyssynchronous heart failure and their reversibility induced by cardiac resynchronization therapy. We focus upon the molecular portrait of dyssynchronous heart failure and how cardiac resynchronization therapy influences electrophysiologic, metabolic and adrenergic pathways.
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