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Updated: Jun 7, 2026

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
08:07

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

Published on: April 12, 2019

Expression of matrix metalloproteinase regulator, RECK, and its clinical significance in osteosarcoma

Jianda Xu1, Sujia Wu, Xin Shi

  • 1Department of Orthopaedics, School of Medicine, Southern Medical University Guangzhou, Jinling Hospital, 305 East Zhongshan Road, Nanjing 210002, Jiangsu Province, China.

Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
|October 26, 2010
PubMed

Insights

Reversion-inducing cysteine-rich protein with Kazal motifs (RECK) expression is a strong prognostic indicator in osteosarcoma. Higher RECK levels correlate with better survival rates and reduced metastasis, aiding therapy decisions.

Area of Science:

  • Oncology
  • Molecular Biology

Background:

  • Reversion-inducing cysteine-rich protein with Kazal motifs (RECK) is a membrane-anchored inhibitor of matrix metalloproteinases.
  • RECK is implicated in suppressing tumor progression and angiogenesis across various cancers.
  • Its prognostic role in osteosarcoma has not been previously evaluated.

Purpose of the Study:

  • To investigate RECK expression in osteosarcoma tissues.
  • To evaluate the clinical significance and prognostic value of RECK in osteosarcoma patients.

Main Methods:

  • Immunohistochemical analysis of RECK expression in 49 osteosarcoma patient samples.
  • Categorization of RECK expression as weak or strong based on intensity and proportion scores.
  • Statistical analysis including survival rates, correlation with metastasis/recurrence, and multivariate analysis.

Main Results:

  • Strong RECK expression was observed in 55.1% of primary osteosarcoma tumors.
  • Patients with strong RECK expression had a significantly higher 5-year survival rate (81.5%) compared to those with weak expression (36.4%).
  • Reduced RECK expression significantly correlated with increased metastasis and recurrence, and was an independent predictor of poor prognosis.

Conclusions:

  • RECK expression levels serve as a valuable prognostic factor in osteosarcoma.
  • Reduced RECK expression is an independent predictor of poor prognosis in osteosarcoma.
  • RECK status can inform the selection of more adequate therapeutic strategies for individual osteosarcoma patients.

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