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Related Experiment Videos

Plasma fibrinogen levels in stroke.

P Mistry1, K P Chawla, H P Rai

  • 1Department of Medicine, Seth G. S. Medical College, Parel, Bombay, Maharashtra.

Journal of Postgraduate Medicine
|January 1, 1990
PubMed
Summary
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Elevated plasma fibrinogen levels are significantly associated with stroke, independent of common risk factors. However, hypertension exacerbates this fibrinogen increase in stroke patients.

Area of Science:

  • Biochemistry
  • Neurology
  • Clinical Medicine

Background:

  • Plasma fibrinogen is a key protein in the coagulation cascade.
  • Elevated fibrinogen levels have been implicated as a potential risk factor for cardiovascular events.
  • Understanding fibrinogen's role in stroke pathogenesis is crucial for risk stratification.

Purpose of the Study:

  • To investigate plasma fibrinogen levels in acute stroke patients.
  • To determine if elevated fibrinogen levels are stroke-specific or associated with risk factors.
  • To assess the impact of hypertension on fibrinogen levels in stroke.

Main Methods:

  • Plasma fibrinogen levels were measured in 56 acute stroke patients within 24 hours of symptom onset.
  • Comparison with age- and sex-matched healthy controls.

Related Experiment Videos

  • Analysis of fibrinogen levels in stroke patients with specific risk factors (hypertension, smoking, alcoholism, atherosclerosis) against controls with similar risk factors.

    • Main Results:

    • Stroke patients exhibited significantly higher plasma fibrinogen levels (531.73 +/- 74 mg%) compared to controls (445.78 +/- 92.28 mg%).
    • The increase in fibrinogen was significant across stroke groups with hypertension, smoking, alcoholism, and atherosclerosis, suggesting a link to stroke itself.
    • Hypertensive stroke patients showed a significantly greater rise in fibrinogen (554.26 +/- 47.08 mg%) compared to non-hypertensive stroke patients (497.82 +/- 93.12 mg%).

    Conclusions:

    • Elevated plasma fibrinogen is a significant finding in acute stroke, largely independent of common risk factors.
    • Hypertension appears to be an independent contributor to the elevated fibrinogen levels observed in stroke patients.
    • These findings highlight plasma fibrinogen as a potential biomarker and therapeutic target in stroke management, particularly in hypertensive individuals.