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Establishment of a Clinic-based Biorepository
Published on: May 29, 2017
Dermatofibrosarcoma protuberans: 35 patients treated with Mohs micrographic surgery using paraffin sections
W P Tan1, R J Barlow, A Robson
1Dermatological Surgery and Laser Unit, St John's Institute of Dermatology, St Thomas' Hospital, London SE1 7EH, UK. melissatanweeping@yahoo.com.sg
The British Journal of Dermatology
|October 27, 2010
Summary
Mohs micrographic surgery (MMS) effectively treats dermatofibrosarcoma protuberans (DFSP), with no observed tumor persistence in 35 patients. MMS is recommended, particularly for head and neck DFSP, prioritizing tissue conservation.
Area of Science:
- Dermatologic Surgery
- Surgical Oncology
- Oncology
Background:
- Dermatofibrosarcoma protuberans (DFSP) traditionally treated with wide local excision.
- Mohs micrographic surgery (MMS) is increasingly advocated for DFSP management.
Purpose of the Study:
- To evaluate the departmental experience with DFSP treated by MMS.
- To review literature on MMS for DFSP.
Main Methods:
- Retrospective case review of 35 DFSP patients treated between 1998 and 2009.
- Mohs micrographic surgery (MMS) utilizing paraffin-embedded sections.
Main Results:
- Tumor clearance required 1-3 layers of MMS for most patients.
- Median preoperative tumor size was 6 cm², with a median postoperative wound size of 46.8 cm².
- No tumor persistence was observed after a median follow-up of 29.5 months.
Conclusions:
- Mohs micrographic surgery (MMS) demonstrated high efficacy in treating DFSP, with no recurrence in this cohort.
- MMS is recommended as a preferred treatment for DFSP, especially in cosmetically sensitive areas like the head and neck.
