Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Nervous Tissue: Myelin

Nervous Tissue: Myelin

The myelin sheath is a multilayered lipid and protein covering that insulates the axon of a neuron, enhancing the speed of nerve impulse conduction. Axons without this sheath are referred to as unmyelinated. Two types of neuroglia, Schwann cells in the peripheral nervous system (PNS) and oligodendrocytes in the central nervous system (CNS) are responsible for producing myelin sheaths.
Schwann cells begin to form myelin sheaths around axons during fetal development. They wrap around a small...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Quantification of Sonicated Implants from Patients with Osteoarticular Implant Infections.

Antibiotics (Basel, Switzerland)·2026

Same author

Genome-wide association study identifies QTL and candidate genes for grain size and weight in a Triticum turgidum collection.

The plant genome·2025

Same author

Headache as main reason for consultation to a hospital Emergency Department in Spain: a prospective study.

Neurologia·2024

Same author

Dataset for facilitating the calculation of aspect ratio of fibrillated cellulose suspensions based on gel point data.

Data in brief·2024

Same author

Periprosthetic joint infection caused by Haemophilus parainfluenzae. Case report and literature review.

Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia·2023

Same author

Development of 27 new microsatellite markers for the shanny Lipophrys pholis.

Molecular biology reports·2022

Search research articles

Related Experiment Video

Updated: Jun 7, 2026

Experimental Demyelination and Remyelination of Murine Spinal Cord by Focal Injection of Lysolecithin

Experimental Demyelination and Remyelination of Murine Spinal Cord by Focal Injection of Lysolecithin

Published on: March 26, 2015

Hypomyelination in three Weimaraner dogs.

Y Millán¹, J Mascort, A Blanco

¹Department of Comparative Pathology, Veterinary Faculty, University of Córdoba, Córdoba, Spain.

The Journal of Small Animal Practice

|October 27, 2010

Summary

This summary is machine-generated.

Hypomyelination in Weimaraner dogs results from a lack of myelin in the central nervous system (CNS). This study suggests a failure in oligodendrocyte development or potential proteolipid protein (PLP) gene mutations as the cause.

More Related Videos

Coherent Anti-Stokes Raman Spectroscopy (CARS) Application for Imaging Myelination in Brain Slices

Coherent Anti-Stokes Raman Spectroscopy (CARS) Application for Imaging Myelination in Brain Slices

Published on: July 22, 2022

Myelin Oligodendrocyte Glycoprotein (MOG35-55) Induced Experimental Autoimmune Encephalomyelitis (EAE) in C57BL/6 Mice

Myelin Oligodendrocyte Glycoprotein (MOG_35-55) Induced Experimental Autoimmune Encephalomyelitis (EAE) in C57BL/6 Mice

Published on: April 15, 2014

Related Experiment Videos

Last Updated: Jun 7, 2026

Experimental Demyelination and Remyelination of Murine Spinal Cord by Focal Injection of Lysolecithin

Experimental Demyelination and Remyelination of Murine Spinal Cord by Focal Injection of Lysolecithin

Published on: March 26, 2015

Coherent Anti-Stokes Raman Spectroscopy (CARS) Application for Imaging Myelination in Brain Slices

Coherent Anti-Stokes Raman Spectroscopy (CARS) Application for Imaging Myelination in Brain Slices

Published on: July 22, 2022

Myelin Oligodendrocyte Glycoprotein (MOG35-55) Induced Experimental Autoimmune Encephalomyelitis (EAE) in C57BL/6 Mice

Myelin Oligodendrocyte Glycoprotein (MOG_35-55) Induced Experimental Autoimmune Encephalomyelitis (EAE) in C57BL/6 Mice

Published on: April 15, 2014

Area of Science:

Veterinary Neurology
Neurobiology
Canine Genetics

Background:

Hypomyelination syndrome in Weimaraner dogs is a neurological disorder characterized by reduced or absent myelin in the central nervous system (CNS).
Understanding the etiology of this condition is crucial for potential therapeutic strategies and genetic counseling.

Observation:

Histochemical staining revealed generalized pallor in specific spinal cord regions, indicating myelin deficiency.
Immunohistochemical analysis showed weak expression of key myelin proteins (proteolipid protein [PLP] and myelin basic protein [MBP]).

Findings:

A significant decrease in Olig2-positive cells, which are precursors to oligodendrocytes, was observed in demyelinated areas.
These findings suggest a primary failure in myelination or remyelination due to an insufficient oligodendrocyte population.
Alternatively, mutations in the proteolipid protein (PLP) gene could explain the reduced PLP expression, as seen in other species.

Implications:

The study points towards oligodendrocyte developmental failure or genetic mutations as the cause of hypomyelination in Weimaraner dogs.
Further research into PLP gene mutations could offer insights into the specific mechanisms underlying this canine neurological disease.
Identifying the precise cause can aid in developing targeted treatments and diagnostic tools for affected dogs.