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Updated: Jun 7, 2026

Simultaneous Detection of c-Fos Activation from Mesolimbic and Mesocortical Dopamine Reward Sites Following Naive Sugar and Fat Ingestion in Rats
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A role for MAPK and PI-3K signaling pathways in brain-derived neurotrophic factor modification of conditioned taste

Diana V Castillo1, Martha L Escobar

  • 1División de Investigación y E studios de Posgrado, Facultad de Psicología, Universidad Nacional Autónoma de México, Mexico.

Behavioural Brain Research
|October 27, 2010
PubMed

Brain-derived neurotrophic factor (BDNF) has emerged as an important molecular mediator of synaptic plasticity. Our previous studies on the insular cortex (IC), a region of the temporal cortex implicated in the acquisition and storage of conditioned taste aversion (CTA), have demonstrated that the intracortical microinfusion of BDNF induces a lasting potentiation of synaptic efficacy in the projection from the basolateral nucleus of the amygdala (Bla) to the IC of adult rats in vivo. Recently, we have found that intracortical microinfusion of BDNF previous to CTA training modifies the retention of this task. In this work, we present experimental data showing that BDNF effects on CTA retention are dependent on both the activation of mitogen-activated protein kinases (MAPK) and phosphatidylinositol-3-kinase (PI-3K) at the insular cortex. Our results are evidence of the crucial role of both pathways in the modification of the CTA trace of memory caused by BDNF at a neocortical area.

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