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Aging and HIV infection.

Vivian Iida Avelino-Silva1, Yeh-Li Ho, Thiago Junqueira Avelino-Silva

  • 1Infectious and Parasitic Diseases Division, Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo - Avenida Dr. Eneas de Carvalho Aguiar 255, 4° Andar do Instituto Central, Sala 4028 - 05403-000-Sao Paulo, SP, Brazil. viviansilva87@gmail.com

Ageing Research Reviews
|October 27, 2010
PubMed
Summary

Older adults with HIV experience faster disease progression and poorer immune function. However, they show better treatment adherence and virologic response to antiretroviral therapy, highlighting its clinical benefit.

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Area of Science:

  • Gerontology
  • Immunology
  • Infectious Diseases

Background:

  • Global population aging is increasing.
  • HIV infection rates are rising among older individuals.
  • Age impacts HIV progression and immune response.

Purpose of the Study:

  • Evaluate current knowledge on HIV infection in older patients.
  • Understand the interplay between aging and HIV in the immune system.

Main Methods:

  • Comprehensive literature review.
  • Analysis of studies from the past 20 years.

Main Results:

  • Older HIV patients present with lower CD4(+) T cell counts, higher viral loads, and more symptoms at diagnosis.
  • HIV infection progresses more rapidly in older adults, leading to increased morbidity and mortality.
  • Despite immune system changes, older patients demonstrate higher adherence and better virologic response to antiretroviral treatment, indicating positive clinical impact.

Conclusions:

  • Both aging and HIV contribute to immune dysfunction, increased morbidity, and mortality.
  • Highly active antiretroviral therapy (HAART) is effective and beneficial for older HIV patients.
  • Treatment for HIV in older adults should be actively pursued and not discouraged.