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Related Experiment Video

Updated: Jun 7, 2026

Assessment of Lymphocyte Migration in an Ex Vivo Transmigration System

Assessment of Lymphocyte Migration in an Ex Vivo Transmigration System

Published on: September 20, 2019

Biomaterial guides for lymphatic endothelial cell alignment and migration.

Echoe M Bouta¹, Connor W McCarthy, Alexander Keim

¹Department of Biomedical Engineering, Michigan Technological University, Houghton, MI 49931-1295, USA.

Acta Biomaterialia

|October 27, 2010

Summary

This study developed a biodegradable conduit with aligned fibers to repair lymphatic vessels damaged by breast cancer surgery. Optimized fibers promote endothelial cell migration, potentially preventing secondary lymphedema.

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Last Updated: Jun 7, 2026

Assessment of Lymphocyte Migration in an Ex Vivo Transmigration System

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Published on: September 20, 2019

Murine Dermal Lymphatic Endothelial Cell Isolation

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Published on: July 21, 2023

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

Published on: May 1, 2015

Area of Science:

Biomaterials Engineering
Regenerative Medicine
Surgical Oncology

Background:

Axillary dissection for breast cancer causes lymphatic damage, leading to secondary lymphedema.
Current treatments for lymphedema are limited, highlighting the need for novel reconstructive strategies.

Purpose of the Study:

To develop and optimize a biodegradable conduit with electrospun fibers for lymphatic vessel reconstruction.
To investigate the effect of fiber alignment and density on lymphatic endothelial cell (LEC) migration in vitro.

Main Methods:

Human LECs were seeded onto 2D substrates with aligned, randomly oriented, or no electrospun fibers of varying diameters and densities.
Cell alignment and migration were quantified using microscopy.
The preservation of fiber alignment in a tubular structure mimicking a lymphatic vessel was assessed.

Main Results:

LECs aligned with the direction of aligned fibers; random orientation occurred on random fibers.
Optimal LEC migration occurred on aligned fibers with 1300 nm diameter and low density.
Blood endothelial cells showed similar responses. Fiber alignment was maintained in a tubular configuration.

Conclusions:

Aligned electrospun fibers within a biodegradable conduit can promote endothelial cell migration.
This approach may facilitate lymphatic vessel reconstruction and potentially mitigate secondary lymphedema post-surgery.
Endothelial cell migration appears independent of lymphatic growth factors in this model.