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Interictal pain in cluster headache.

Michael J Marmura¹, Scott J Pello, William B Young

¹Thomas Jefferson University, Philadelphia, PA, USA. Michael.marmura@jefferson.edu

Cephalalgia : an International Journal of Headache

|October 27, 2010

Summary

Persistent pain between cluster headache attacks may indicate a more severe disease. This finding suggests interictal pain could predict chronic cluster, allodynia, and poor treatment response.

Area of Science:

Neurology
Headache Medicine

Background:

Cluster headache presents with severe unilateral pain.
Some patients report migraine-like symptoms, including persistent pain.

Purpose of the Study:

To investigate clinical characteristics of cluster headache patients.
To determine the prevalence and nature of interictal pain in cluster headache.

Main Methods:

Utilized questionnaires and chart reviews for data collection.
Evaluated 50 cluster headache patients.

Main Results:

24 out of 50 subjects reported pain outside of acute attacks.
16 subjects experienced persistent pain more than half the time during their cycle.
This interictal pain was generally mild, unlike acute attacks.

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Conclusions:

Persistent interictal pain is associated with chronic cluster headache.
Interictal pain may predict allodynia and suboptimal response to sumatriptan.
Suggests interictal pain indicates a more severe cluster headache disease process.