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Updated: Jun 7, 2026

Evaluation of T Follicular Helper Cells and Germinal Center Response During Influenza A Virus Infection in Mice
Published on: June 27, 2020
FcγRIV deletion reveals its central role for IgG2a and IgG2b activity in vivo
Falk Nimmerjahn1, Anja Lux, Heike Albert
1Department of Biology, Institute of Genetics, University of Erlangen-Nuremberg, 91058 Erlangen, Germany. fnimmerj@biologie.uni-erlangen.de
Abstract:
Cellular Fcγ receptors are essential for IgG-dependent effector functions in vivo. There is convincing evidence that selective activating Fcγ receptors are responsible for the activity of individual IgG subclasses. Thus, IgG1 activity is absent in FcγRIII-deficient mice, and several studies suggest that the activity of the most potent IgG subclasses, IgG2a and IgG2b, might be dependent on either individual or a combination of activating FcγRs. To study the role of individual activating FcγRs for IgG subclass activity, we generated an FcγRIV-deficient mouse and showed that a variety of IgG2a- and IgG2b-dependent effector functions are impaired in the absence of this activating Fc receptor in models of autoimmunity and antibody-dependent cellular cytotoxicity.
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