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Related Concept Videos

Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids01:25

Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids

Inhaled corticosteroids (ICS) are anti-inflammatory drugs used primarily in treating persistent asthma and providing long-term maintenance. They target the bronchial mucosa, the lining of the airways, to control inflammation, a critical factor in asthma progression and exacerbation.
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
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Asthma-IV: Diagnostic and Management

The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
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Asthma III: Clinical Manifestations01:13

Asthma III: Clinical Manifestations

Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

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Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
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Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...

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Related Experiment Video

Updated: Jun 7, 2026

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
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Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels

Published on: August 7, 2017

Peripheral glucocorticoid sensitivity in children with controlled persistent asthma.

Guilherme C Müller1, Paulo M Pitrez, Rejane Fialho Matias Lopes

  • 1Laboratory of Cellular and Molecular Immunology, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre, Brazil.

Neuroimmunomodulation
|October 27, 2010
PubMed
Summary

Children with persistent asthma show normal sensitivity to glucocorticoids (GCs), even with severe disease. This suggests GC resistance in older children with severe asthma may be acquired, not inherent.

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Last Updated: Jun 7, 2026

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Area of Science:

  • Pediatric Pulmonology
  • Immunology
  • Pharmacology

Background:

  • Persistent asthma in children is a chronic inflammatory condition managed primarily with glucocorticoids (GCs).
  • Steroid resistance is known in severe asthma, but its presence in controlled childhood asthma is unstudied.

Purpose of the Study:

  • To investigate the sensitivity of peripheral blood mononuclear cells (PBMCs) to GCs in children aged 6-15 with persistent asthma compared to healthy controls.

Main Methods:

  • PBMCs were isolated from children with persistent asthma (divided into mild, moderate, severe groups) and healthy controls.
  • In vitro assays assessed mitogen-induced proliferation and cellular sensitivity to dexamethasone.

Main Results:

  • Children with controlled persistent asthma, irrespective of severity, exhibited similar GC sensitivity to healthy children.
  • Mild asthma cases showed significantly less dexamethasone sensitivity, while severe asthma cases had comparable sensitivity to controls.

Conclusions:

  • In vitro GC insensitivity was not observed in children with controlled persistent asthma, including severe cases.
  • GC resistance in older children with severe asthma might be an acquired condition, warranting further longitudinal investigation.