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[Acenocoumarol and vasculitis - a rare case].

Pedro Abreu¹, Cátia Duarte, Armando Malcata

¹Serviço de Reumatologia – Hospitais da Universidade de Coimbra, Coimbra. pmabreu@aeiou.pt

Acta Reumatologica Portuguesa

|October 27, 2010

Summary

A 62-year-old man developed widespread purple skin lesions. Discontinuation of acenocoumarol led to spontaneous resolution, suggesting a rare drug-induced vasculitis.

Area of Science:

Dermatology
Internal Medicine
Pharmacology

Background:

Acenocoumarol is an anticoagulant medication.
Vasculitis is inflammation of blood vessels.

Observation:

A 62-year-old male presented with a three-week history of insidious onset, widespread purpuric skin lesions.
Lesions were purple, round, confluent, and affected the entire body, including palms and soles.
Initial laboratory tests were normal; a skin biopsy was performed.

Findings:

Following exclusion of other causes, acenocoumarol was discontinued.
The purpuric lesions resolved spontaneously within one week of medication cessation.
The temporal relationship and resolution strongly suggested acenocoumarol-induced vasculitis.

Related Experiment Videos

Implications:

This case highlights a rare adverse reaction to acenocoumarol.
It underscores the importance of considering drug-induced vasculitis in patients presenting with purpuric lesions.
Clinicians should be vigilant for uncommon side effects of long-term anticoagulant therapy.