Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jun 7, 2026

DNAzyme 10-23 - Based Nanomachines for Nucleic Acid Recognition
07:16

DNAzyme 10-23 - Based Nanomachines for Nucleic Acid Recognition

Published on: February 9, 2024

Motion-based DNA detection using catalytic nanomotors.

Jie Wu1, Shankar Balasubramanian, Daniel Kagan

  • 1Department of Nanoengineering, University of California San Diego, La Jolla, CA 92093, USA.

Nature Communications
|October 27, 2010
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Beta 2 adrenergic receptor agonists as a treatment for metabolic dysfunction-associated steatohepatitis (MASH).

npj metabolic health and disease·2026
Same author

Neuronal expression of Retinoid-Related Orphan Receptor Gamma (RORγ) and revisiting its role in the Central Nervous System.

bioRxiv : the preprint server for biology·2026
Same author

A Study on the Bioavailability of a Proprietary, Sustained-release Formulation of Astaxanthin.

Integrative medicine (Encinitas, Calif.)·2019
Same author

Bioavailability of a Sustained Release Formulation of Curcumin.

Integrative medicine (Encinitas, Calif.)·2016
Same author

Acoustic droplet vaporization and propulsion of perfluorocarbon-loaded microbullets for targeted tissue penetration and deformation.

Angewandte Chemie (International ed. in English)·2012
Same author

Effect of CCR5-Δ32 heterozygosity on HIV-1 susceptibility: a meta-analysis.

PloS one·2012
Same journal

Chlorinated VSLSs Surpass HCFCs in CFC-11-Equivalent Emissions for Ozone Layer Depletion in China.

Nature communications·2026
Same journal

Author Correction: Charge transfer in triphenylamine-tetrazine covalent organic frameworks for solar-driven hydrogen peroxide production.

Nature communications·2026
Same journal

Vegetation browning patterns under compound soil and atmospheric dryness in northern permafrost ecosystems.

Nature communications·2026
Same journal

Voltage imaging of CA1 pyramidal cells and SST+ interneurons reveals stability and plasticity mechanisms of spatial firing.

Nature communications·2026
Same journal

Radical-omics reveals the hydrogen-abstraction pathway of isoprene oxidation.

Nature communications·2026
Same journal

Toughening elastomer via sequentially activated multi-pathway energy dissipation.

Nature communications·2026
See all related articles

Synthetic nanomotors offer a fast, simple, and sensitive method for detecting DNA and bacterial ribosomal RNA. This novel approach utilizes changes in nanomotor speed to signal the presence of specific biological targets.

Area of Science:

  • Nanotechnology
  • Biotechnology
  • Biosensing

Background:

  • Synthetic nanomotors convert chemical energy into autonomous motion, showing potential for various applications.
  • Current biosensing methods can be complex and time-consuming.

Purpose of the Study:

  • To demonstrate the use of synthetic nanomotors for fast, simple, and sensitive detection of DNA and bacterial ribosomal RNA.
  • To introduce a novel motion-driven biodetection strategy.

Main Methods:

  • Utilized unmodified catalytic nanomotors whose speed changes are measured.
  • Employed a sandwich DNA hybridization assay with silver nanoparticle tags.
  • Visualized concentration-dependent signals using optical microscopy and magnetically aligned nanomotors.

More Related Videos

Production of Dynein and Kinesin Motor Ensembles on DNA Origami Nanostructures for Single Molecule Observation
08:09

Production of Dynein and Kinesin Motor Ensembles on DNA Origami Nanostructures for Single Molecule Observation

Published on: October 15, 2019

Folding and Characterization of a Bio-responsive Robot from DNA Origami
07:59

Folding and Characterization of a Bio-responsive Robot from DNA Origami

Published on: December 3, 2015

Related Experiment Videos

Last Updated: Jun 7, 2026

DNAzyme 10-23 - Based Nanomachines for Nucleic Acid Recognition
07:16

DNAzyme 10-23 - Based Nanomachines for Nucleic Acid Recognition

Published on: February 9, 2024

Production of Dynein and Kinesin Motor Ensembles on DNA Origami Nanostructures for Single Molecule Observation
08:09

Production of Dynein and Kinesin Motor Ensembles on DNA Origami Nanostructures for Single Molecule Observation

Published on: October 15, 2019

Folding and Characterization of a Bio-responsive Robot from DNA Origami
07:59

Folding and Characterization of a Bio-responsive Robot from DNA Origami

Published on: December 3, 2015

Main Results:

  • Successfully detected DNA and bacterial ribosomal RNA using the nanomotor speed changes.
  • Demonstrated a concentration-dependent signal transduction visualized through nanomotor movement.

Conclusions:

  • The nanomotor biodetection strategy provides a versatile and powerful tool for detecting biological targets.
  • This approach can be extended to monitor various biomolecular interactions using different motion transduction schemes.