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KIF6 p.Trp719Arg Testing to Assess Risk of Coronary Artery Disease and/or Statin Response
Diane Allingham-Hawkins1, Andrew Lea, Susan Levine
1Hayes, Inc.
Abstract:
Coronary artery disease (CAD) is a leading cause of death worldwide and in the United States it is responsible for more than 500,000 deaths each year. Genome-wide association studies (GWAS) have revealed connections between a number of common single nucleotide polymorphisms (SNPs) and CAD and other cardiovascular diseases. The p.Trp719Arg SNP in the kinesin-like family 6 (KIF6) gene has recently been reported as a potential risk factor for CAD as well as a predictor of response to statin therapy.
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