Related Experiment Video
Updated: Jun 7, 2026

08:28
Analysis of Congenital Heart Defects in Mouse Embryos Using Qualitative and Quantitative Histological Methods
Published on: March 10, 2020
Congenital malformations in Assam.
Hemonta Kr Dutta1, N C Bhattacharyya, J N Sarma
1Department of Pediatric Surgery, Assam Medical College, Dibrugarh, Assam - 786 002, India.
Journal of Indian Association of Pediatric Surgeons
|October 27, 2010
Summary
The 2006 Assam study found a congenital malformation incidence of 0.08%, lower than other Indian states. Gastrointestinal and genitourinary systems were most affected, with central nervous system malformations varying by ethnic group.
Area of Science:
- Medical Research
- Public Health
- Pediatrics
Background:
- Congenital malformations represent a significant global health concern.
- Understanding regional variations in incidence is crucial for targeted interventions.
Purpose of the Study:
- To ascertain the annual incidence of congenital malformations in Assam.
- To analyze demographic and systemic patterns of these malformations.
Main Methods:
- Retrospective analysis of data from babies born in Assam in 2006.
- Data collection via questionnaires.
- Comparison with existing Indian data.
Main Results:
- Overall incidence of congenital malformation was 0.08%.
- Males (65.4%) were more affected than females (34.6%).
- Gastrointestinal (26%) and genitourinary (25.8%) systems were most commonly affected; CNS malformations showed ethnic variation.
Conclusions:
- The incidence of congenital malformations in Assam was lower than reported in other Indian states.
- Specific malformation patterns, particularly involving the central nervous system, differed across ethnic groups.
Related Concept Videos
Teratogenicity
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
Neurulation
Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the anterior...
Genomic Imprinting and Inheritance
Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
Sex-linked Disorders
Like autosomes, sex chromosomes contain a variety of genes necessary for normal body function. When a mutation in one of these genes results in biological deficits, the disorder is considered sex-linked.
Mismatch Repair
Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the new strand and replacing the erroneous bases with correct nucleotides. Mismatch repair is coordinated by many proteins in both prokaryotes and eukaryotes.
The Mutator Protein Family Plays a Key Role in DNA Mismatch Repair
The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...
The Mutator Protein Family Plays a Key Role in DNA Mismatch Repair
The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...

