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Related Concept Videos

Teratogenicity01:07

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
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Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the anterior...
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Genomic Imprinting and Inheritance

Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
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Related Experiment Video

Updated: Jun 7, 2026

Analysis of Congenital Heart Defects in Mouse Embryos Using Qualitative and Quantitative Histological Methods
08:28

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Published on: March 10, 2020

Congenital malformations in Assam.

Hemonta Kr Dutta1, N C Bhattacharyya, J N Sarma

  • 1Department of Pediatric Surgery, Assam Medical College, Dibrugarh, Assam - 786 002, India.

Journal of Indian Association of Pediatric Surgeons
|October 27, 2010
PubMed
Summary

The 2006 Assam study found a congenital malformation incidence of 0.08%, lower than other Indian states. Gastrointestinal and genitourinary systems were most affected, with central nervous system malformations varying by ethnic group.

Keywords:
Congenital anomalycongenital malformationpediatric

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Area of Science:

  • Medical Research
  • Public Health
  • Pediatrics

Background:

  • Congenital malformations represent a significant global health concern.
  • Understanding regional variations in incidence is crucial for targeted interventions.

Purpose of the Study:

  • To ascertain the annual incidence of congenital malformations in Assam.
  • To analyze demographic and systemic patterns of these malformations.

Main Methods:

  • Retrospective analysis of data from babies born in Assam in 2006.
  • Data collection via questionnaires.
  • Comparison with existing Indian data.

Main Results:

  • Overall incidence of congenital malformation was 0.08%.
  • Males (65.4%) were more affected than females (34.6%).
  • Gastrointestinal (26%) and genitourinary (25.8%) systems were most commonly affected; CNS malformations showed ethnic variation.

Conclusions:

  • The incidence of congenital malformations in Assam was lower than reported in other Indian states.
  • Specific malformation patterns, particularly involving the central nervous system, differed across ethnic groups.