Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Shuttle-box avoidance facilitation by minaprine in mice.

M Sansone1, M Battaglia, J Vetulani

  • 1Istituto di Psicobiologia e Psicofarmacologia, CNR, Roma, Italy.

Polish Journal of Pharmacology and Pharmacy
|July 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Searches for B meson decays to phiphi, phirho, phif_{0}(980), and f_{0}(980)f_{0}(980) final states.

Physical review letters·2008
Same author

Measurement of the branching fractions of B-->D**(l) nu(l) decays in events tagged by a fully reconstructed B meson.

Physical review letters·2008
Same author

Dysfunctional DC subsets in RCC patients: ex vivo correction to yield an effective anti-cancer vaccine.

Molecular immunology·2008
Same author

Penile prosthesis: what should we do about complications?

Advances in urology·2008
Same author

Observation and polarization measurements of B+/- -->phiK1 +/- and B +/- -->phiK2 *+/-.

Physical review letters·2008
Same author

Measurement of the CP asymmetry in b-->sgamma using a sum of exclusive final states.

Physical review letters·2008

The new antidepressant minaprine improved shuttle-box avoidance learning in mice after pretreatment, while desipramine showed no significant effect. Further research is needed to understand minaprine's mechanism in enhancing avoidance performance.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Behavioral Science

Background:

  • Antidepressants are investigated for their effects on cognitive functions.
  • Minaprine is a novel antidepressant with potential nootropic properties.
  • Desipramine is a classical tricyclic antidepressant used as a comparator.

Purpose of the Study:

  • To evaluate the impact of minaprine and desipramine on shuttle-box avoidance acquisition in mice.
  • To determine if drug pretreatment influences the effects of these antidepressants on learning.
  • To compare the efficacy of a new antidepressant (minaprine) with a classical one (desipramine) in a learning task.

Main Methods:

  • CD-1 strain mice were trained in a shuttle-box avoidance task over five daily sessions.
  • Animals received minaprine (1-10 mg/kg) or desipramine (0.5-5 mg/kg) with or without 5-day pretreatment.

Related Experiment Videos

  • Locomotor activity was monitored to assess potential confounding effects.

    • Main Results:

    • Minaprine at 10 mg/kg significantly facilitated avoidance acquisition in pretreated mice.
    • This facilitating dose of minaprine did not affect spontaneous locomotor activity.
    • Desipramine did not produce any significant effects on shuttle-box avoidance responses.

    Conclusions:

    • Minaprine demonstrates potential as a cognitive enhancer, specifically improving avoidance learning.
    • The facilitative effect of minaprine on learning was observed after a pretreatment period.
    • The precise neurobiological mechanisms underlying minaprine's positive effects on learning remain to be elucidated.