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Derivatives of (R,S)-1-N-(theophyllinyl-7'-ethyl)-amino-2-propanol with antiarrhythmic activity
M Eckstein1, J Zajaczkowska, L Samochowiec
1Department of Chemical Technology of Drugs, Copernicus Medical Academy, Kraków, Poland.
Polish Journal of Pharmacology and Pharmacy
|July 1, 1990
Abstract:
Three (R,S)-1-N-(theophyllinyl-7'-ethyl)-amino-2-propanol derivatives were obtained as soluble hydrochlorides and tested in four models of experimental arrhythmia. Two compounds 1a and 2 have shown antiarrhythmic properties and very low toxicity.