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Updated: Jun 7, 2026

Synthesis of a Thiol Building Block for the Crystallization of a Semiconducting Gyroidal Metal-sulfur Framework
Published on: April 9, 2018
OXIDATION OF THIOLS USING K(2)S(2)O(8) IN IONIC LIQUID.
Abdol R Hajipour1, Majid Mostafavi, Arnold E Ruoho
1Dept. of Pharmacology, University of Wisconsin, Medical School, 1300 University Avenue, Madison, 53706-1532, WI, USA.
A novel green chemistry method efficiently oxidizes thiols to disulfides using potassium persulfate in an ionic liquid. This straightforward approach yields excellent results in a short time.
Area of Science:
- Green chemistry
- Organic synthesis
- Oxidation reactions
Background:
- Oxidation of thiols to disulfides is a crucial transformation in organic chemistry.
- Developing efficient and environmentally friendly oxidation methods is an ongoing challenge.
Purpose of the Study:
- To report a novel, green, and straightforward method for thiol oxidation.
- To utilize an ionic liquid as a reaction medium for enhanced efficiency.
Main Methods:
- Oxidation of thiols using potassium persulfate (K(2)S(2)O(8)).
- Employing the ionic liquid 1-butyl-3-methylimidazolium bromide [(bmim)Br] as the solvent.
- Conducting the reaction at a temperature of 65-70 °C.
Main Results:
- Achieved excellent yields of the corresponding disulfides.
- Demonstrated short reaction times for the oxidation process.
- The method is characterized by its simplicity and environmental friendliness.
Conclusions:
- The reported method offers an efficient and green alternative for synthesizing disulfides.
- Ionic liquids can serve as effective media for oxidation reactions.
- This approach is suitable for the straightforward preparation of disulfides from thiols.
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