Related Experiment Videos
X-linked agammaglobulinemia complicated with endobronchial tuberculosis
Chihiro Kawakami1, Akiko Inoue, Kimitaka Takitani
1Department of Pediatrics, Osaka Medical College, Takatsuki, Osaka, Japan. ped076@poh.osaka-med.ac.jp
Aim:
We report a case of X-linked agammaglobulinemia complicated with endobronchial tuberculosis.
Methods:
We observed the patient's clinical course and analysed his data retrospectively.
Results:
Interestingly, the T-cell proliferation activity in this patient was intact, and the CD4-positive T cells produced interferon gamma. However, the result of the quantiferon alpha-2b test was negative.
Conclusion:
The findings of this case suggest that the quantiferon alpha-2b test may not be diagnostic for tuberculosis not only in patients with T-cell disorders but also in cases with B-cell deficiencies such as X-linked agammaglobulinemia.
Related Concept Videos
Pulmonary Tuberculosis II
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Pulmonary Tuberculosis I
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Tuberculosis
Pulmonary Tuberculosis III
The first classification is based on the development of the disease, and it includes the following categories:
Pulmonary Tuberculosis V
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the progression...
Pulmonary Tuberculosis IV
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...