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Updated: Jun 7, 2026

Growing Neural Stem Cells from Conventional and Nonconventional Regions of the Adult Rodent Brain
Published on: November 18, 2013
p73 regulates maintenance of neural stem cell
Massimiliano Agostini1, Paola Tucci, Hailan Chen
1Medical Research Council, Toxicology Unit, Leicester University, Leicester LE1 9HN, UK.
The p73 protein, particularly TAp73, is crucial for maintaining neural stem cells (NSC). Studies show TAp73 supports NSC proliferation and neurogenesis, vital for brain development.
Area of Science:
- Neuroscience
- Molecular Biology
- Stem Cell Research
Background:
- The p53 family, including p73, are critical transcription factors in cellular processes.
- Neural stem cells (NSCs) are vital for brain development and repair.
- The role of p73 in neural stem cell maintenance is not fully understood.
Purpose of the Study:
- To investigate the role of TAp73 in neural stem cell (NSC) proliferation and differentiation.
- To determine the impact of p73 deficiency on neurogenesis in vivo and in vitro.
Main Methods:
- Analysis of TAp73 expression in neural stem cells during differentiation.
- Assessment of NSC proliferation and gene expression (Sox-2, Notch) in p73 null mice.
- Histological analysis of neurogenic areas in the brains of p73-/- mice.
Main Results:
- TAp73 is expressed in neural stem cells, with increased levels upon differentiation.
- p73 null mice exhibit reduced NSC proliferative potential and decreased Sox-2 and Notch gene expression.
- In vivo studies show reduced neurogenic area width in p73-/- mice.
Conclusions:
- TAp73 plays a significant role in maintaining the neural stem cell pool.
- p73 is essential for proper NSC proliferation and neurogenesis.
- These findings highlight p73 as a key regulator in neural stem cell biology.
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