Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Functional Brain Systems: Limbic System01:15

Functional Brain Systems: Limbic System

7.3K
The limbic system, often called the "emotional brain," is a complex set of structures located deep within the brain. The intricate network of the limbic system supports a wide range of psychological functions, from emotional regulation to memory formation and sensory processing. This functional brain region encompasses specific parts of the diencephalon and the cerebrum, integrating the higher mental functions of the cerebral cortex with the primitive emotional responses of the deep brain...
7.3K
Transcription Attenuation in Prokaryotes02:42

Transcription Attenuation in Prokaryotes

18.4K
Transcriptional attenuation occurs when RNA transcription is prematurely terminated due to the formation of a terminator mRNA hairpin structure.  Bacteria use these hairpins to regulate the transcription process and control the synthesis of several amino acids including histidine, lysine, threonine, and phenylalanine. Transcription attenuation takes place in the non-coding regions of mRNA.
There are several different mechanisms used to attenuate transcription. In ribosome mediated...
18.4K
Apoptosis01:30

Apoptosis

14.5K
Apoptosis is a combination of two Greek words, 'apo' and 'ptosis,' meaning separation and falling off, respectively. Hippocrates used this word to describe gangrene, which was caused due to bandaging of fractured bones. Apoptosis was distinguished from necrosis in 1970 when John Kerr reported observations of morphological changes occurring during apoptosis. During one experiment, he observed that the disruption of blood supply to the liver tissue resulted in a size...
14.5K
Neurons as Communicators of the Brain01:22

Neurons as Communicators of the Brain

3.2K
Neurons, the fundamental units of the brain and nervous system, function as the primary transmitters of information throughout the body. Their ability to communicate through electrical and chemical signals is vital for every bodily function, from regulating the heartbeat to processing complex thoughts. Each neuron has three main components: the cell body (soma), dendrites, and an axon, each specialized to facilitate swift and efficient neural communication.
Cell Body
The cell body, also known...
3.2K
Higher Mental Functions of the Brain: Language01:10

Higher Mental Functions of the Brain: Language

3.8K
Language is a system of communication that allows the expression of thoughts, ideas, and feelings. The brain processes language in both hemispheres.
Language formation and comprehension take place in the dominant hemisphere. The dominant hemisphere is responsible for understanding the meaning of spoken, written, or sign language, as well as the ability to communicate. For most people, the left hemisphere is the dominant one. The right hemisphere, then, gives tone and emotional context to the...
3.8K
Higher Mental Functions of Brain: Learning and Memory01:26

Higher Mental Functions of Brain: Learning and Memory

2.1K
Memory is one of the most vital higher mental functions of the brain. Memory is closely related to learning because it enables us to retain information and experiences from our past to use them in our present life. It also helps us to remember facts, events, and skills, such as riding a bike or swimming. There are two types of memory — declarative memory, which involves memorizing facts or events, and procedural memory, which enables us to remember how to do something like writing or...
2.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Foliar application of licorice-wolfberry derived nanomaterials enhances soybean heat tolerance through maintaining reactive oxygen species homeostasis.

Frontiers in plant science·2026
Same author

Effects of microbial inoculants and planting density on soybean summer-sown growth, nutrients accumulation and yield in Southern Xinjiang.

Frontiers in plant science·2026
Same author

Preparation and Performance Study of Three-Layer Composite Filter Media for Channel-Type Ultra-Low Penetration Air Filters.

Nanomaterials (Basel, Switzerland)·2026
Same author

Identification of mitochondrial-related subtypes and development of a prognostic model for pancreatic ductal adenocarcinoma.

Journal of gastrointestinal oncology·2026
Same author

Dual-activated fluorescent probe for the study of the mechanism of SO<sub>2</sub> and NO in cisplatin resistance of nasopharyngeal carcinoma.

RSC advances·2026
Same author

Trimester-specific reference intervals for serum N-acetyl-β-D-glucosaminidase in healthy pregnant women in Hainan, China.

European journal of obstetrics & gynecology and reproductive biology: X·2026

Related Experiment Video

Updated: Jan 30, 2026

Neurobehavioral Assessments in a Mouse Model of Neonatal Hypoxic-ischemic Brain Injury
08:32

Neurobehavioral Assessments in a Mouse Model of Neonatal Hypoxic-ischemic Brain Injury

Published on: November 24, 2017

12.9K

Mild hypothermia improves ischemic brain function via attenuating neuronal apoptosis.

He Li1, Desheng Wang

  • 1Department of Neurology, the First Clinical Medical College of Harbin Medical University, Harbin 150001, China. hrblihe@yahoo.com.cn

Brain Research
|October 28, 2010
PubMed
Summary

Mild hypothermia therapy protects brain cells from ischemic stroke by reducing apoptotic cell death. This neuroprotective effect was observed in rats, showing improved brain function and lower SMAC expression.

More Related Videos

A Novel Model of Mild Traumatic Brain Injury for Juvenile Rats
07:36

A Novel Model of Mild Traumatic Brain Injury for Juvenile Rats

Published on: December 8, 2014

24.4K
Investigations on Alterations of Hippocampal Circuit Function Following Mild Traumatic Brain Injury
10:59

Investigations on Alterations of Hippocampal Circuit Function Following Mild Traumatic Brain Injury

Published on: November 19, 2012

15.9K

Related Experiment Videos

Last Updated: Jan 30, 2026

Neurobehavioral Assessments in a Mouse Model of Neonatal Hypoxic-ischemic Brain Injury
08:32

Neurobehavioral Assessments in a Mouse Model of Neonatal Hypoxic-ischemic Brain Injury

Published on: November 24, 2017

12.9K
A Novel Model of Mild Traumatic Brain Injury for Juvenile Rats
07:36

A Novel Model of Mild Traumatic Brain Injury for Juvenile Rats

Published on: December 8, 2014

24.4K
Investigations on Alterations of Hippocampal Circuit Function Following Mild Traumatic Brain Injury
10:59

Investigations on Alterations of Hippocampal Circuit Function Following Mild Traumatic Brain Injury

Published on: November 19, 2012

15.9K

Area of Science:

  • Neuroscience
  • Cell Biology
  • Biochemistry

Background:

  • Ischemic stroke poses a significant threat to brain cells.
  • Hypothermia is a potential therapeutic strategy for neuroprotection.
  • Molecular mechanisms of hypothermic neuroprotection require further elucidation.

Purpose of the Study:

  • To investigate the molecular mechanisms of hypothermic neuroprotection in ischemic stroke.
  • To assess the impact of mild hypothermia on neurological impairment and apoptosis.

Main Methods:

  • Animal model: Rats subjected to ischemia under normothermia and mild hypothermia.
  • Quantitative analysis of neurological impairment scores.
  • Measurement of second mitochondrion-derived activator of caspases (SMAC) expression as an apoptosis index.

Main Results:

  • Mild hypothermia significantly improved brain function compared to normothermia.
  • Hypothermia treatment led to a significant reduction in SMAC expression.
  • These findings suggest hypothermia attenuates apoptotic cell death.

Conclusions:

  • Mild hypothermia offers neuroprotection against ischemic injury.
  • The mechanism involves the attenuation of apoptotic pathways, indicated by reduced SMAC levels.
  • Hypothermia represents a promising therapeutic approach for ischemic stroke.