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Tissue Renewal without Stem Cells

Tissue Renewal without Stem Cells

After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
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Apoptosis

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Apoptosis is a combination of two Greek words, 'apo' and 'ptosis,' meaning separation and falling off, respectively. Hippocrates used this word to describe gangrene, which was caused due to bandaging of fractured bones. Apoptosis was distinguished from necrosis in 1970 when John Kerr reported observations of morphological changes occurring during apoptosis. During one experiment, he observed that the disruption of blood supply to the liver tissue resulted in a size reduction of the tissue.

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Related Experiment Video

Updated: Jun 7, 2026

Flow Cytometric Detection of Newly-formed Breast Cancer Stem Cell-like Cells After Apoptosis Reversal

Flow Cytometric Detection of Newly-formed Breast Cancer Stem Cell-like Cells After Apoptosis Reversal

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Apoptosis, stem cells, and tissue regeneration.

Andreas Bergmann¹, Hermann Steller

¹Department of Biochemistry and Molecular Biology, M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.

Science Signaling

|October 28, 2010

Summary

Cell death signals, specifically apoptotic caspases, unexpectedly promote tissue regeneration by stimulating stem and progenitor cell proliferation. This finding links cell death mechanisms to regenerative processes in various organisms.

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Strategies for Tracking Anastasis, A Cell Survival Phenomenon that Reverses Apoptosis

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Last Updated: Jun 7, 2026

Flow Cytometric Detection of Newly-formed Breast Cancer Stem Cell-like Cells After Apoptosis Reversal

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Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In Situ

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Strategies for Tracking Anastasis, A Cell Survival Phenomenon that Reverses Apoptosis

Strategies for Tracking Anastasis, A Cell Survival Phenomenon that Reverses Apoptosis

Published on: February 16, 2015

Area of Science:

Cell Biology
Developmental Biology
Regenerative Medicine

Background:

Metazoans exhibit varying regenerative capacities, crucial for tissue homeostasis and repair after injury.
Regeneration involves cell proliferation, differentiation, and patterning, with stem and progenitor cells playing key roles.
Model organisms like amphibians, planarians, and Hydra showcase significant regenerative abilities.

Purpose of the Study:

To review key findings on tissue regeneration.
To explore the role of apoptotic caspases in stimulating stem and progenitor cell proliferation during regeneration.
To discuss the connections between stem cell biology, regeneration, and cancer.

Main Methods:

Review of existing studies primarily from Drosophila, Hydra, Xenopus, and mouse.
Analysis of molecular mechanisms underlying tissue regeneration.
Focus on the role of apoptotic caspases and mitogenic signaling.

Main Results:

Apoptotic caspases, traditionally linked to cell death, produce mitogenic signals.
These signals stimulate the proliferation of stem and progenitor cells, aiding tissue regeneration.
The findings highlight an unexpected link between apoptosis and regeneration.

Conclusions:

Apoptotic caspases are crucial regulators of stem and progenitor cell proliferation in regeneration.
Understanding this pathway offers new insights into regenerative medicine and cancer biology.
Further research can explore therapeutic applications targeting this mechanism.